Community-based tuberculosis triage testing for hard-to-reach populations in Southern Africa
Publications
Accuracy and Acceptability of the VISITECT CD4 Advanced Disease Test Compared With the PIMA CD4 Test at the Point of Care as Part of the Advanced HIV Disease Care Package: A Mixed-Methods Study. Gils T, Misra S, Madonsela T, Pita TP, Bosman S, Ayakaka I, Vlieghe E, van Heerden A, Lynen L, Decroo T, Reither K. Open Forum Infect Dis. 2026 Jan 29;13(2):ofag043. doi: 10.1093/ofid/ofag043. eCollection 2026 Feb.PMID: 41725708
Effectiveness and cost-effectiveness of community-based TB screening algorithms using computer-aided detection (CAD) technology alone compared with CAD combined with point-of-care C reactive protein testing in Lesotho and South Africa: protocol for a paired screen-positive trial. Signorell A, van Heerden A, Ayakaka I, Jacobs BK, Antillon M, Tediosi F, Verjans A, Brugger C, Harkare HV, Labhardt ND, Bosman S, Kamele M, Keitseng M, Madonsela T, Kurscheid J, Muhairwe J, Keter AK, Murphy K, van Ginneken B, Gils T, Katende B, Gebresenbet RF, Erhardt RM, Zoller T, Vanobberghen F, Glass TR, Lynen L, Reither K. BMJ Open. 2025 Jul 28;15(7):e093989. PMID: 40721262
“If your CD4 count lowers, that is when you are similar to a person that is non-existent” A qualitative exploration of perceptions around advanced HIV disease in South Africa. Pita TP, Misra S, Madonsela T, Tshazi A, Bosman S, Ayakaka I, Vlieghe E, Decroo T, Reither K, van Heerden A, Gils T. BMC Public Health. 2025 Jul 3;25(1):2325. PMID: 40610975
Performance of CAD4TB artificial intelligence technology in TB screening programmes among the adult population in South Africa and Lesotho. Nzimande N, Murphy K, Reither K, Bosman S, Ayakaka I, Glass TR, Vanobberghen F, Jacobs BKM, Signorell A, Ncayiyana J. J Clin Tuberc Other Mycobact Dis. 2025 Jun 4;40:100540. PMID: 40547074
Estimation of therapeutic threshold for tuberculosis using adapted nominal group technique and clinical vignettes in clinical and community settings in Southern Africa. Keter AK, Heerden AV, Decroo T, Boyles T, Bosman S, Madonsela T, Msimango LI, Naiken L, Kiyan C, Kamele M, Ayakaka I, Reither K, Mario Jacobs BK, Lynen L.J Clin Tuberc Other Mycobact Dis. 2025., PMID: 40351511
Evaluation of C-Reactive Protein and Computer-Aided Analysis of Chest X-rays as Tuberculosis Triage Tests at Health. Bosman S, Ayakaka I, Muhairwe J, Kamele M, van Heerden A, Madonsela T, Labhardt ND, Sommer G, Bremerich J, Zoller T, Murphy K, van Ginneken B, Keter AK, Jacobs BKM, Bresser M, Signorell A, Glass TR, Lynen L, Reither K. Facilities in Lesotho and South Africa. Clin Infect Dis. 2024 Aug 27:ciae378.
Simultaneous alleviation of verification and reference standard biases in a community-based tuberculosis screening study using Bayesian latent class analysis.Keter AK, Vanobberghen F, Lynen L, Van Heerden A, Fehr J, Olivier S, Wong EB, Glass TR, Reither K, Goetghebeur E, Jacobs BKM.PLoS One. 2024 Jun 10;19(6):e0305126. PMID: 38857227.
Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms. Vanobberghen F, Keter AK, Jacobs BKM, Glass TR, Lynen L, Law I, Murphy K, van Ginneken B, Ayakaka I, van Heerden A, Maama L, Reither K. ERJ Open Res. 2024 Jan 8;10(1):00508-2023. doi: 10.1183/23120541.00508-2023. eCollection 2024 Jan. PMID: 38196890.
Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: A mixed-methods evaluation. Gils T, Kamele M, Madonsela T, Bosman S, Ngubane T, Joseph P, Reither K, Bresser M, Vlieghe E, Decroo T, Ayakaka I, Lynen L, Van Heerden A. PLoS One. 2023 Dec 22;18(12):e0296197. doi: 10.1371/journal.pone.0296197. eCollection 2023. PMID: 38134020.
COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests. Murphy K, Muhairwe J, Schalekamp S, van Ginneken B, Ayakaka I, Mashaete K, Katende B, van Heerden A, Bosman S, Madonsela T, Gonzalez Fernandez L, Signorell A, Bresser M, Reither K, Glass TR. Sci Rep. 2023 Nov 11;13(1):19692. doi: 10.1038/s41598-023-46461-w. PMID: 37952026.
Incidental radiological findings during clinical tuberculosis screening in Lesotho and South Africa: a case series. Glaser N, Bosman S, Madonsela T, van Heerden A, Mashaete K, Katende B, Ayakaka I, Murphy K, Signorell A, Lynen L, Bremerich J, Reither K. J Med Case Rep. 2023 Aug 25;17(1):365. doi: 10.1186/s13256-023-04097-4. PMID: 37620921.
Evaluation of tuberculosis diagnostic test accuracy using Bayesian latent class analysis in the presence of conditional dependence between the diagnostic tests used in a community-based tuberculosis screening study. Keter AK, Lynen L, Van Heerden A, Wong E, Reither K, Goetghebeur E, Jacobs BKM. PLoS One. 2023 Mar 2;18(3):e0282417. doi: 10.1371/journal.pone.0282417. eCollection 2023. PMID: 36862729.
Feasibility of implementing the advanced HIV disease care package as part of community-based HIV/TB activities: a mixed-methods study protocol. Gils T, Lynen L, Muhairwe J, Mashaete K, Lejone TI, Joseph P, Ngubane T, Keter AK, Reither K, van Heerden A. BMJ Open. 2022 Feb 7;12(2):e057291. doi: 10.1136/bmjopen-2021-057291. PMID: 35131835.
Implications of covariate induced test dependence on the diagnostic accuracy of latent class analysis in pulmonary tuberculosis. Keter AK, Lynen L, Van Heerden A, Goetghebeur E, Jacobs BKM. J Clin Tuberc Other Mycobact Dis. 2022 Sep 6;29:100331. doi: 10.1016/j.jctube.2022.100331. eCollection 2022 Dec. PMID: 36111071.
