Community-based tuberculosis triage testing for hard-to-reach populations in South Africa and Lesotho


Trying to find “the missing TB cases”


Worldwide, only 2/3 of the new TB cases are currently notified to national authorities and reported to WHO

(WHO report 2019)





at a glance

Tuberculosis is a poverty-related disease which particularly affects vulnerable and underserved populations. The World Health Organization has developed target product profiles for community-based TB triage testing. CAD4TB, an extensively validated digital chest x-ray analysis platform using deep-learning technology, and a blood test for C-reactive protein, which is a marker of inflammation or infection, are two very promising diagnostic tools which have the potential to meet the targets for TB triage.

The 5-year African-European TB TRIAGE+ project is funded by the European and Developing Countries Clinical Trials Partnership (EDCTP) and will assess the accuracy, impact and cost-effectiveness of CAD4TB and  C-reactive protein as triage tools for community-based TB screening in rural and semi-rural Lesotho and KwaZulu-Natal, South Africa.


We are pleased to announce recruitment start for TB TRIAGE+ TRIAL in September 2022 at both of our sites South Africa and Lesotho!